期刊论文

Banerjee, Ipsita

英文

BMC Systems Biology

1752-0509

2012

6

1

1-13

10.1186/1752-0509-6-154

NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005, UL1TR000005] Funding Source: NIH RePORTER; NATIONAL CENTER FOR RESEARCH RESOURCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR) [UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153, UL1RR024153] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R00DK083556, R00DK083556, R00DK083556] Funding Source: NIH RePORTER; OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [DP2OD006491] Funding Source: NIH RePORTER; NCATS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1 TR000005] Funding Source: Medline; NCRR NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR) [UL1 RR024153] Funding Source: Medline; NIDDK NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R00 DK083556] Funding Source: Medline

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Background: Lineage specific differentiation of human embryonic stem cells (hESCs) is largely mediated by specific growth factors and extracellular matrix molecules. Growth factors initiate a cascade of signals which control gene transcription and cell fate specification. There is a lot of interest in inducing hESCs to an endoderm fate which serves as a pathway towards more functional cell types like the pancreatic cells. Research over the past decade has established several robust pathways for deriving endoderm from hESCs, with the capability ...