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Up-regulation of the mRNA-transcripts of VR1 and NGF induced by air formaldehyde

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成果类型:
期刊论文、会议论文
作者:
Tong, ZQ;Yang, X*;Yan, Y;Liu, J;Lu, ZS;...
通讯作者:
Yang, X
作者机构:
[Liu, J; Lu, ZS; Tong, ZQ; Yan, Y; Li, CM; Kang, YY; Yang, X] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
通讯机构:
[Yang, X] C
Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
formaldehyde (FM);vanilloid receptor substype-1 (VR1);nerve growth factor (NGF)
期刊:
INDOOR AIR 2005: PROCEEDINGS OF THE 10TH INTERNATIONAL CONFERENCE ON INDOOR AIR QUALITY AND CLIMATE, VOLS 1-5
ISSN:
0908-5920
年:
2005
卷:
15
页码:
3844-3850
会议名称:
10th International Conference on Indoor Air Quality and Climate (Indoor Air 2005)
会议时间:
SEP 04-09, 2005
会议地点:
Beijing, PEOPLES R CHINA
会议主办单位:
Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
会议赞助商:
Tsinghua Univ, Minist Educ China, Natl Nat Sci Fdn China, Beijing Municipal Commiss Sci & Technol, Shanghai Municipal Commiss Sci & Technol, US EPA, Amer Ind Hyg Assoc, Amer Soc Heating, Refrigerating & Air Conditioning Engineers, Int Commiss Occupat Hlth, SC Indoor Air Qual & Hlth, Int Council Res & Innovat Bldg & Construct, European Commiss Asia Pro Eco Programme Promot Sustainable Solut Environm Europe & Asia, Korean Soc Indoor Environm, Soc Indoor Environm
主编:
Yang, X Zhao, B Zhao, R
出版地:
TSINGHUA UNIV HAIDIANQU, BEIJING 100084, PEOPLES R CHINA
出版者:
TSINGHUA UNIV PRESS
ISBN:
978-7-89494-830-4
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
The purpose of the present study was to determine gene expression pattern of chemosensitive receptor VR1 in the brain stem of the neonatal rat after low-level gaseous formaldehyde exposure. Male Sprague-Dawley newborn rats were exposed to clean air or 1.8 mg/m(3) formaldehyde for consecutive 72 h and the brain stems were dissected for RNA extraction. The mRNA levels of VR1 and cytokine NGF gene were determined with semiquantitative RT-PCR. We observed that the mRNA expression of VR1 and NGF was significantly increased in the brain of the tested neonatal rats. These findings suggest that succes...

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