期刊论文

Feng, Lingling（冯玲玲）;He, Hongwu

英文

Bioorganic & Medicinal Chemistry

0968-0896

2019

27

12

2413-2420

10.1016/j.bmc.2019.01.021

The work was supported by National Research and Development Plan (No. 2017YFD0200506), the Natural Science Foundation of China (No. 21877047 , 21472062 , 21877046 , 21867011 , 21472061 and 31701820 ), and the Project of the Science Fund of Jiangxi Education Office (GJJ170672), the Project of Hubei Natural Science Foundation (2017CFB232), China postdoctoral science foundation (2017M622486). The work was also financially supported by self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (CCNU18ZDPY02) and the Program of Introducing Talents of Discipline to Universities of China (111 program, B17019).

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Cyanobacterial pyruvate dehydrogenase multienzyme complex E1 (PDHc E1)is a potential target enzyme for finding inhibitors to control harmful cyanobacterial blooms. In this study, a series of novel triazole thiamin diphosphate (ThDP)analogs were designed and synthesized by modifying the substituent group of triazole ring and optimizing triazole-benzene linker as potential cyanobacterial PDHc E1 (Cy-PDHc E1)inhibitors. Their inhibitory activities against Cy-PDHc E1 in vitro and algicide activities in vivo were further examined. Most of these comp...