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Direct synthesis of 2-methylpyridines via I2-triggered [3 + 2 + 1] annulation of aryl methyl ketoxime acetates with triethylamine as the carbon source

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成果类型:
期刊论文
作者:
Gao, Qinghe*;Yan, Huijuan;Wu, Manman;Sun, Jiajia;Yan, Xiqing;...
通讯作者:
Gao, Qinghe
作者机构:
[Yan, Xiqing; Wu, Manman; Sun, Jiajia; Yan, Huijuan; Gao, Qinghe] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China.
[Wu, Anxin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Gao, Qinghe] X
Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China.
语种:
英文
期刊:
Organic & Biomolecular Chemistry
ISSN:
1477-0520
年:
2018
卷:
16
期:
13
页码:
2342-2348
基金类别:
This work was supported by the National Natural Science Foundation of China (Grant 21605127). This work was also supported by the Xinxiang Innovative Technology Team (Grant CXTD17004). Dr X. Yan acknowledges the Scientific &
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
A facile and efficient [3 + 2 + 1] annulation of aryl methyl ketoxime acetates and triethylamine for the synthesis of 2-methylpyridines was disclosed. This reaction demonstrated that I-2 was effective in triggering N-O bond cleavage of oxime acetates generating imine radicals. It was noteworthy that this transformation employed triethylamine as the carbon source for the direct formati...

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