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Direct synthesis of 2-methylpyridines via I2-triggered [3 + 2 + 1] annulation of aryl methyl ketoxime acetates with triethylamine as the carbon source

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成果类型:
期刊论文
作者:
Gao, Qinghe*;Yan, Huijuan;Wu, Manman;Sun, Jiajia;Yan, Xiqing;...
通讯作者:
Gao, Qinghe
作者机构:
[Yan, Xiqing; Wu, Manman; Sun, Jiajia; Yan, Huijuan; Gao, Qinghe] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China.
[Wu, Anxin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Gao, Qinghe] X
Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China.
语种:
英文
期刊:
Organic & Biomolecular Chemistry
ISSN:
1477-0520
年:
2018
卷:
16
期:
13
页码:
2342-2348
基金类别:
Scientific & Technological Project of Henan Province [172102310616]; Xinxiang Innovative Technology Team [CXTD17004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21605127]
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
A facile and efficient [3 + 2 + 1] annulation of aryl methyl ketoxime acetates and triethylamine for the synthesis of 2-methylpyridines was disclosed. This reaction demonstrated that I-2 was effective in triggering N-O bond cleavage of oxime acetates generating imine radicals. It was noteworthy that this transformation employed triethylamine as the carbon source for the direct formati...

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