Neurodegenerative diseases (ND) affect a large and ever-growing population globally, resulting in heavy burdens for patients and their families. Though some specific genes related to ND have been identified, the genetic factors fail to fully account for the pathogenesis of ND. Therefore, the roles of the environment and life styles in the occurrence of ND are being actively probed. As a typical air pollutant, exposures to PM2.5 are linked to the occurrence of ND. However, there are still few studies on this exposure, particularly on the in vivo and molecular mechanisms of the ND-like lesions a...