期刊论文

Wu, Yandong

英文

ChemistrySelect

2365-6549

2017

2

33

10762-10765

10.1002/slct.201702044

We are grateful to the National Natural Science Foundation of China (Grant Nos. 21602070, 21472056) and the Fundamental Research Funds for the Central Universities (CCNU15ZX002 and CCNU16 A05002) for financial support. This work was also supported by the 111 Project B17019. We also thank Dr. Chuanqi Zhou, Hebei University, for analytical support.

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A novel benzoic acid-promoted intermolecular 1,3-dipolar cycloaddition reaction has been developed for the one-pot construction of biologically important pyrrolo[2, 1-a]isoquinolines. This metal-free reaction between dipolarophiles and in situ-generated azomethine ylides avoids the pre-preparation of N-substituted substrates and allows for the efficient formation of one C−N bond and two C−C bonds. ©...