会议论文

Synthesis and Biological Activity of Novel Protoporphyrinogen Oxidase Inhibitors

中文

2013

199-203

第十届全国新农药创制学术交流会

第十届全国新农药创制学术交流会论文集

2013-05-01

济南

中化化工科学技术研究院

本校为第一机构

选择原卟啉原氧化酶(PPO酶)的***啉酮衍生物作为主要研究方向,以取代苯胺为原料通过几步关啉酮环、取代、硝化、还原以及关噻唑环等反应,合成了9个巯基被酯类酰胺取代的新化合物.并对所有合成的新化合物进行了人体及烟草PPO酶的抑制活性测试,部分化合物表现出了一定的选择性.

　　The dissertation chose protoporphyrinogen oxidase inhibitor (Triazolinone derivatives)as research project.Using substituted anilines as startingmaterials,9 novel compounds were synthesized.Their chemical structures were confirmed by 1HNMR and GC-MS.The in vitro PPO inhibition of these novel target compounds were assayed,and the bioassay results ...