Acute formaldehyde exposure induced early Alzheimer-like changes in mouse brain

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成果类型：

期刊论文

作者：

Liu, Xudong;Zhang, Yuchao;Wu, Ruliu;Ye, Meng;Zhao, Yuqing;...

通讯作者：

Yang, Xu

作者机构：

[Wu, Ruliu; Zhao, Yuqing; Li, Jinquan; Yang, Xu; Kang, Jun; Ye, Meng; Liu, Xudong] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Lab Environm Biomed, Wuhan, Hubei, Peoples R China.

[Zhang, Yuchao; Liu, Xudong] Moutai Coll, Dept Food Sci & Engn, Renhuai, Peoples R China.

[Ma, Ping] Hubei Univ Sci & Technol, Sch Basic Med Sci, Res Ctr Basic Med Sci, Xianning, Peoples R China.

[Li, Jinquan] NYU, Sch Med, Tuxedo Pk, NY USA.

[Yang, Xu] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Yang, Xu] C

Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

关键词：

Alzheimer's disease;early Alzheimer-like changes;formaldehyde;inflammation;oxidative stress

期刊：

Toxicology Mechanisms and Methods

ISSN：

1537-6516

年：

2018

卷：

期：

页码：

95-104

DOI：

10.1080/15376516.2017.1368053

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21577045]; Hubei Province Health and Family Planning Scientific Research Project [WJ2017Z027]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Alzheimer’s disease (AD) is a serious, common, global disease, yet its etiology and pathogenesis are incompletely understood. Although an association between AD and exposure to air pollutants has been discussed, the effects of pollutants on the functioning of the brain remain unclear. The indoor environment is where exposure to formaldehyde (FA) can occur. Whether exposure to FA contributes to the development of AD needs to be investigated. To determine the objective, C57BL/6 mice were exposed daily to FA (0, 0.155, 1.55 and 15.5 mg/kg/day) fo...

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Acute formaldehyde exposure induced early Alzheimer-like changes in mouse brain

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