期刊论文

中文

化学研究与应用

1004-1656

2003

15

4

585-587

10.3969/j.issn.1004-1656.2003.04.049

湖北省自然科学基金（2000J014）； 华中师范大学校基金资助课题；

本校为第一机构

磺酰脲(胺)作为一类抑制乙酰乳酸合成酶(ALS)活性的除草剂,具有剂量小,选择性强,杀草谱广,对哺乳动物毒性低,在环境中不易积聚等特点,成为除草剂研究的热点[1-4].本文采用"亚结构连接法",将含饱和杂环(芳环)磺酰胺引入到芳氧羧酸中,试图降低药物对作物产生的毒副作用与抗药性,同时提高其除草活性.8个目标化合物的合成路线如下:

In order to search for new types of herbicides,a series of ethyl 4 hetercyclic(aryl)amino sulfonyl phenoxy acetates(propionates) were synthesized by the condensation reactions of 4 ethoxycarbonylmethylenoxy(ethoxy)phenyl sulfonyl chlorides and saturated heterocyclic(aryl)amines.Their structures were confirmed by 1H NMR,IR,MS and elemental analysis.The results of biloassays showed that some of ...