Design of a Metallacycle-Based Supramolecular Photosensitizer for In Vivo Image-Guided Photodynamic Inactivation of Bacteria

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xu, Yuling;Tuo, Wei;Yang, Liang;Sun, Yan;Li, Chonglu;...

通讯作者：

Yang, Guangfu;Sun, Yao;Stang, Peter J.

作者机构：

[Xu, Yuling; Yang, Guangfu; Yang, Wenchao; Yang, GF; Sun, Yao] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.

[Stang, Peter J.; Tuo, Wei; Sun, Yan] Univ Utah, Dept Chem, 315 South 1400 East,Room 2020, Salt Lake City, UT 84112 USA.

[Yang, Liang] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Radiol, Wuhan 430022, Peoples R China.

[Li, Chonglu] Guangxi Med Univ, Guangxi Key Lab High Incidence Tumor Prevent & Tr, Nanning 530021, Peoples R China.

[Chen, Xiaoqiang] Nanjing Univ Technol, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China.

通讯机构：

[Yang, GF; Sun, Y] C

[Stang, Peter J.] U

Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.

Univ Utah, Dept Chem, 315 South 1400 East,Room 2020, Salt Lake City, UT 84112 USA.

语种：

英文

关键词：

antimicrobial;metallacycle;photodynamic inactivation;supramolecule

期刊：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ISSN：

1433-7851

年：

2022

卷：

期：

页码：

e202110048-

DOI：

10.1002/anie.202110048

基金类别：

This work was supported by National Natural Science Foundation of China 22022404, 22074050, and 21708012, Wuhan Scientific and Technological Projects 2019020701011441, self‐determined research funds of CCNU from the colleges, basic research and operation of MOE for the Central Universities (CCNU20QN010), the State Key Laboratory of Materials‐Oriented Chemical Engineering (KL20‐05), the Opening Project of Guangxi Key Laboratory of High‐Incidence‐Tumor Prevention & Treatment (GKE‐KF202005).

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Bacterial infection is one of the greatest threats to public health. In vivo real-time monitoring and effective treatment of infected sites through non-invasive techniques, remain a challenge. Herein, we designed a PtII metallacycle-based supramolecular photosensitizer through the host-guest interaction between a pillar[5]arene-modified metallacycle and 1-butyl-4-[4-(diphenylamino)styryl]pyridinium. Leveraging the aggregation-induced emission supramolecular photosensitizer, we improved fluorescence performance and antimicrobial photodynamic ina...

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Design of a Metallacycle-Based Supramolecular Photosensitizer for In Vivo Image-Guided Photodynamic Inactivation of Bacteria

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