Scientific Research Foundation for Returned Overseas Chinese Scholars (State Education Ministry)Scientific Research Foundation for the Returned Overseas Chinese Scholars [2010-1174]
机构署名：
本校为第一且通讯机构
院系归属：
化学学院
摘要：
The main objective of this study was to design a suitable drug delivery system for 10-hydroxycamptothecin (HCPT). In this study, HCPT-loaded solid lipid nanoparticle (HCPT-loaded SLN) was successfully prepared. The HCPT-loaded SLN was characterized by size, entrapment efficiency and drug release manner. The cytotoxicity of HCPT-loaded SLN was assessed in vitro using HepG2/HCPT cells and in vivo utilizing human tumor xenograft nude mouse model. HCPT-loaded SLN indicated the ability to target HepG2/HCPT cells and accumulated higher drug content i...
