In perturbative QCD approach, based on the first order of isospin symmetry breaking, we study the direct CP violation in the decay of B¯s0ρωK∗0π+π-K∗0. An interesting mechanism is applied to enlarge the CP violating asymmetry involving the charge symmetry breaking between ρ and ω. We find that the CP violation is large by the ρ-ω mixing mechanism when the invariant masses of the π+π- pairs are in the vicinity of the ω resonance. For the decay process of B¯s0ρωK∗0π+π-K∗0, the maximum CP violation can reach -59.12%. Furthermo...