Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium(II) Metallacycle.

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成果类型：

期刊论文

作者：

Tu, Le;Li, Chonglu;Ding, Qihang;Sharma, Amit;Li, Meiqin;...

作者机构：

[Tu, Le; Li, Meiqin; Li, Junrong; Sun, Yao; Li, Chonglu] National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China

[Li, Chonglu] State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China

[Kim, Jong Seung; Ding, Qihang] Department of Chemistry, Korea University, Seoul 02841, Korea

[Sharma, Amit] Amity School of Chemical Sciences, Amity University Punjab, Sector 82A, Mohali, Punjab 140306, India

语种：

英文

期刊：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ISSN：

0002-7863

年：

2024

卷：

146

期：

页码：

8991-9003

DOI：

10.1021/jacs.3c13224

机构署名：

本校为第一机构

院系归属：

化学学院

摘要：

Though immunogenic cell death (ICD) has garnered significant attention in the realm of anticancer therapies, effectively stimulating strong immune responses with minimal side effects in deep-seated tumors remains challenging. Herein, we introduce a novel self-assembled near-infrared-light-activated ruthenium(II) metallacycle, Ru1105 (λ(em) = 1105 nm), as a first example of a Ru(II) supramolecular ICD inducer. Ru1105 synergistically potentiates immunomodulatory responses and reduces adverse effects in deep-seated tumors through multiple regulat...

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Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium(II) Metallacycle.

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