期刊论文

Xiao, YT

英文

Communications Biology

2399-3642

2023

6

1

1064

10.1038/s42003-023-05447-0

This project was funded by the Sci-Tech Innovation 2030 Agenda (2022ZD04021), National Natural Science Foundation of China (32372546), Shenzhen Science and Technology Program (KQTD20180411143628272), the Agricultural Science and Technology Innovation Progr [2022ZD04021]; Sci-Tech Innovation 2030 Agenda [32372546]; National Natural Science Foundation of China [KQTD20180411143628272]; Shenzhen Science and Technology Program [JCYJ20190813115612564]; Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences and Major projects of basic research of Science, Shenzhen Science and Technology Project; Innovation Commission of Shenzhen Municipality

本校为其他机构

The rapid evolution of resistance in agricultural pest poses a serious threat to global food security. However, the mechanisms of resistance through metabolic regulation are largely unknown. Here, we found that a GST gene cluster was strongly selected in North China (NTC) population, and it was significantly genetically-linked to lambda-cyhalothrin resistance. Knockout of the GST cluster using CRISPR/Cas9 significantly increased the sensitivity of the knockout strain to lambda-cyhalothrin. Haplotype analysis revealed no non-synonymous mutations or structural variations in the GST cluster, wher...