Site-specific N-glycan characterization of grass carp serum IgM

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成果类型：

期刊论文

作者：

Su, Yi-Ling;Wang, Bing;Hu, Meng-Die;Cui, Zheng-Wei;Wan, Jian;...

通讯作者：

Geng, Hui;Zhang, Yong-An

作者机构：

[Yang, Qian; Xiong, Li; Wan, Cui-Hong; Su, Yi-Ling; Wan, Jian; Wang, Bing; Hu, Meng-Die; Bai, Hao; Geng, Hui] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.

[Zhang, Yong-An; Cui, Zheng-Wei] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China.

[Cui, Zheng-Wei] Univ Chinese Acad Sci, Coll Modem Agr Sci, Beijing, Peoples R China.

[Cui, Yan-Fang] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Hubei, Peoples R China.

[Zhang, Yong-An] Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China.

通讯机构：

[Geng, Hui; Zhang, Yong-An] C

[Zhang, Yong-An] H

[Zhang, Yong-An] Q

Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.

Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

N-glycan;glycosylation;grass carp;immunoglobulin M;liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS);matrix assisted laser desorption/ionization-time-of-flight-MS (MALDI-TOF-MS);teleost

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2018

卷：

期：

NOV

页码：

2645

DOI：

10.3389/fimmu.2018.02645

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21473065]; Fundamental Research Funds for the Central University of Central China Normal University [CCNU16A02044]; Hubei Province Natural Science Key Foundation Project [2014CFA079]; National Basic Research Program of ChinaNational Basic Research Program of China [2014CB138601]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

化学学院

摘要：

Immunoglobulin M (IgM) is the major antibody in teleost fish and plays an important role in humoral adaptive immunity. The N-linked carbohydrates presenting on IgM have been well documented in higher vertebrates, but little is known regarding site-specific N-glycan characteristics in teleost IgM. In order to characterize these site-specific N-glycans, we conducted the first study of the N-glycans of each glycosylation site of the grass carp serum IgM. Among the four glycosylation sites, the Asn-262, Asn-303, and Asn-426 residues were efficientl...

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Site-specific N-glycan characterization of grass carp serum IgM

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