Risk factors for oxaliplatin-induced hypersensitivity reaction in patients with colorectal cancer

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成果类型：

期刊论文

作者：

Song, Qiuyan;Cai, Yuanxuan;Guo, Kangyuan;Li, Min;Yu, Zaoqin;...

通讯作者：

Zhang, CL;Zhu, X

作者机构：

[Tai, Qirui; Song, Qiuyan] Kunming Med Univ, Affiliated Hosp 6, Dept Pharm, Yuxi 653100, Yunnan, Peoples R China.

[Cai, Yuanxuan; Zhang, Chengliang; Zhao, Yuhang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China.

[Guo, Kangyuan] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Wuhan 430030, Hubei, Peoples R China.

[Li, Min; Zhang, Chengliang; Yu, Zaoqin] Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China.

[Zhu, Xuan; Zhu, X] Cent China Normal Univ, Sch Comp, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Zhang, CL ] H

[Zhu, X ] C

Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China.

Cent China Normal Univ, Sch Comp, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

关键词：

Chinese population;multivariate analysis;allergic history;OXA-free interval

期刊：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

ISSN：

1943-8141

年：

2022

卷：

期：

页码：

2461-2468

基金类别：

National Natural Science Foundation of China [71874062, 71503089]; Funding for Research-Oriented Clinician Plan of Tongji Medical College, Huazhong University of Science and Technology [5001540076]; Clinical Toxicology Foundation of Chinese Society of Toxicology [CST2020CT-107]

机构署名：

本校为通讯机构

院系归属：

计算机学院

摘要：

Objective: Hypersensitivity reactions with oxaliplatin (OXA) have attracted much attention. This study aimed to analyze the risk factors for OXA-induced hypersensitivity reaction in Chinese colorectal cancer patients through a single center retrospective investigation. Methods: The information from 459 colorectal cancer patients treated with OXA in a hospital was collected retrospectively to explore the risk factors for OXA-induced hypersensitivity reaction. Results: Among the 459 patients, 47 (10.24% incidence) cases developed hypersensitivity reactions, with a 3.70% incidence of grade III/IV...

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Risk factors for oxaliplatin-induced hypersensitivity reaction in patients with colorectal cancer

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