Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system

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成果类型：

期刊论文

作者：

Gao, Xiao;Xu, Ke;Du, Wanting;Wang, Shuxin;Jiang, Mengling;...

通讯作者：

Mingqing Chen

作者机构：

[Xu, Ke; Jiang, Mengling; Wang, Shuxin; Han, Qi; Gao, Xiao; Du, Wanting; Wang, Yunyi] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China

[Chen, Mingqing] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China. Electronic address: chenmq@mail.ccnu.edu.cn

通讯机构：

[Mingqing Chen] H

Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China

语种：

英文

关键词：

Functional groups;Modified nanoparticles;Nanoplastics;Reproductive toxicity;mTOR

期刊：

Science of The Total Environment

ISSN：

0048-9697

年：

2024

卷：

922

页码：

171299

DOI：

10.1016/j.scitotenv.2024.171299

基金类别：

CRediT authorship contribution statement Xiao Gao: Data curation, Investigation, Methodology, Validation, Writing – original draft. Ke Xu: Conceptualization, Investigation, Methodology. Wanting Du: Investigation, Methodology. Shuxin Wang: Investigation, Methodology. Mengling Jiang: Investigation. Yunyi Wang: Investigation, Software. Qi Han: Investigation, Software. Mingqing Chen: Conceptualization, acquisition, Methodology, Project administration, Supervision, Writing – review & editing.

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

After aging in the environment, some nanoplastics will carry different charges and functional groups, thereby altering their toxicological effects. To evaluate the potential impact of aging of nanoplastics on the mammalian reproductive system, we exposed C57BL/6 male mice to a dose of 5mg/kg/d polystyrene nanoparticles (PS-NPs) with different functional groups (unmodified, carboxyl functionalized and amino functionalized) for 45days for this study. The results suggest that PS-NPs with different functional groups triggered oxidative stress, a decreased in the testis index, disruption of the out...

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Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system

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