Oxidative damage induced by chlorpyrifos in the hepatic and renal tissue of Kunming mice and the antioxidant role of vitamin E

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成果类型：

期刊论文

作者：

Ma, Ping;Wu, Yang;Zeng, Qiang;Gan, Yaping;Chen, Jiaoe;...

通讯作者：

Yang, Xu

作者机构：

[Chen, Jiaoe; Gan, Yaping; Ma, Ping] Hubei Univ Sci & Technol, Coll Basic Med Sci, Xianning 437100, Peoples R China.

[Wu, Yang; Ye, Xin; Yang, Xu; Ma, Ping; Zeng, Qiang] Cent China Normal Univ, Coll Life Sci, Sect Environm Biomed, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Yang, Xu] Huazhong Normal Univ, Coll Life Sci, Lab Environm Biomed, Bldg 5,152 Luo Yu Rd, Wuhan 430079, Peoples R China.

通讯机构：

[Yang, Xu] H

Huazhong Normal Univ, Coll Life Sci, Lab Environm Biomed, Bldg 5,152 Luo Yu Rd, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

8-Hydroxy-2-deoxyguanosine;Chlorpyrifos;DNA-protein crosslinks;Malondialdehyde;Oxidative stress;Vitamin E

期刊：

Food and Chemical Toxicology

ISSN：

0278-6915

年：

2013

卷：

页码：

177-183

DOI：

10.1016/j.fct.2013.04.032

基金类别：

Science and Technology Research Foundation from Hubei Education Department [D20122803]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51136002]

机构署名：

本校为通讯机构

院系归属：

生命科学学院

摘要：

Chlorpyrifos is a broad-spectrum, chlorinated organophosphate pesticide employed for pest control in various agricultural and animal husbandries. Acute and chronic exposure to CPF can elicit several adverse effects, including oxidative stress. We investigated neurotoxicity of CPF-treated mice, and evaluated the antioxidant effect of vitamin E against oxidative stress and histological changes in the livers and kidneys of CPF-treated mice. Kunming mice were divided randomly into five exposure groups of six: (A) peanut oil; (B) 3. mg/kg CPF; (C) 6...

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Oxidative damage induced by chlorpyrifos in the hepatic and renal tissue of Kunming mice and the antioxidant role of vitamin E

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