Objective To study the change of frequency tuning in inferior collicular neurons when added weak noise forward masking. Methods We examined the changes in neuronal frequency tuning resulted from a weak white noise as forward masking relative to 5dB beyond minimum threshold (reMT+ 5) and different duration (40,60,80,100 ms) under free field stimulation conditions. Results Weak noise forward masking sharpens frequency tuning curves (FTCs) of most neurons ( P 〈 0.01, n = 25). The effect increased with masker duration increasing ( P 〈 0...