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Time delay induced transition of gene switch and stochastic resonance in a genetic transcriptional regulatory model

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成果类型:
期刊论文、会议论文
作者:
Wang, Canjun*;Yi, Ming;Yang, Keli;Yang, Lijian
通讯作者:
Wang, Canjun
作者机构:
[Wang, Canjun; Yang, Keli] Baoji Univ Arts & Sci, Nonlinear Res Inst, Baoji 721016, Peoples R China.
[Yi, Ming] Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China.
[Yi, Ming] Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China.
[Yang, Lijian] Huazhong Normal Univ, Dept Phys, Wuhan 430071, Peoples R China.
[Yang, Lijian] Huazhong Normal Univ, Inst Biophys, Wuhan 430071, Peoples R China.
通讯机构:
[Wang, Canjun] B
Baoji Univ Arts & Sci, Nonlinear Res Inst, Baoji 721016, Peoples R China.
语种:
英文
关键词:
Noise Intensity;Stochastic Resonance;Correlate Noise;Gene Switch;Small Time Delay
期刊:
BMC Systems Biology
ISSN:
1752-0509
年:
2012
卷:
6
期:
1
页码:
S9
会议名称:
5th IEEE International Conference on Computational Systems Biology (ISB)
会议时间:
SEP 02-04, 2011
会议地点:
Zhuhai, PEOPLES R CHINA
会议主办单位:
[Wang, Canjun;Yang, Keli] Baoji Univ Arts & Sci, Nonlinear Res Inst, Baoji 721016, Peoples R China.^[Yi, Ming] Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China.^[Yi, Ming] Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China.^[Yang, Lijian] Huazhong Normal Univ, Dept Phys, Wuhan 430071, Peoples R China.^[Yang, Lijian] Huazhong Normal Univ, Inst Biophys, Wuhan 430071, Peoples R China.
会议赞助商:
CAS, Shanghai Inst Biol Sci (SIBS), CAS, Acad Math & Syst Sci (AMSS), Sun Yat-sen Univ
出版地:
236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
出版者:
BIOMED CENTRAL LTD
基金类别:
This project was supported by the Natural Science Foundation of China (Grant No.11047146 (CJ Wang), Grant No.10905089 (M Yi) and Grant No.11047107 and No.11105058 (LJ Yang)), the Natural Science Foundation of Shaanxi province of China (Grant No.2010JQ1014 (CJ Wang)) and the Science Foundation of Baoji University of Science and Arts of China (Grant No.ZK11053 (CJ Wang)). This article has been published as part of BMC Systems Biology Volume 6 Supplement 1, 2012: Selected articles from The 5th IEEE International Conference on Systems Biology (ISB 2011). The full contents of the supplement are available online at http://www.biomedcentral.com/ bmcsystbiol/supplements/6/S1.
机构署名:
本校为其他机构
院系归属:
物理科学与技术学院
摘要:
Noise, nonlinear interactions, positive and negative feedbacks within signaling pathways, time delays, protein oligomerization, and crosstalk between different pathways are main characters in the regulatory of gene expression. However, only a single noise source or only delay time in the deterministic model is considered in the gene transcriptional regulatory system in previous researches. The combined effects of correlated noise and time delays on the gene regulatory model still remain not to be fully understood. The roles of time delay on gen...

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