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Oral exposure to dibutyl phthalate exacerbates chronic lymphocytic thyroiditis through oxidative stress in female Wistar rats

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成果类型:
期刊论文
作者:
Wu, Yang;Li, Jinquan;Yan, Biao;Zhu, Yuqing;Liu, Xudong;...
通讯作者:
Yang, Xu;Ma, Ping;Lee, Ching-Chang
作者机构:
[Wu, Yang; Yang, X; Ma, Ping; Yang, Xu; Li, Dai; Yan, Biao] Hubei Univ Sci & Technol, Lab Environm Immunol & Neurol Dis, Sch Basic Med Sci, Xianning 437100, Peoples R China.
[Li, Jinquan; Chen, Mingqing; Yang, Xu; Zhu, Yuqing; Liu, Xudong] Cent China Normal Univ, Lab Environm Biomed, Coll Life Sci, Wuhan 430079, Hubei, Peoples R China.
[Lee, Ching-Chang] Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Med Coll, Tainan 70428, Taiwan.
通讯机构:
[Yang, X; Ma, P] H
[Yang, Xu] C
[Lee, Ching-Chang] N
Hubei Univ Sci & Technol, Lab Environm Immunol & Neurol Dis, Sch Basic Med Sci, Xianning 437100, Peoples R China.
Cent China Normal Univ, Lab Environm Biomed, Coll Life Sci, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
期刊:
Scientific Reports
ISSN:
2045-2322
年:
2017
卷:
7
期:
1
页码:
15469
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21507026]; Health and Family Planning Scientific Research Project of Hubei Province [WJ2017Z027]; College Outstanding Young and Middle-aged Innovative Research Team Project of Hubei Province [T201717]
机构署名:
本校为通讯机构
院系归属:
生命科学学院
摘要:
Chronic lymphocytic thyroiditis (CLT) is a common autoimmune disorder. The possible pathogenic role and mechanism of dibutyl phthalate (DBP) in CLT is still controversial. Experiments were conducted after 35-days of oral exposure to the three concentrations of DBP or saline, and three immunizations with thyroglobulin (TG). Healthy female Wistar rats were randomly divided into ten exposure groups (n = 8 each): (A) saline control, (B) 0.5 mg/kg/d DBP, (C) 5 mg/kg/d DBP, (D) 50 mg/kg/d DBP, (E) TG-immunized group, (F) TG- combined with 0.5 mg/kg/d...

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