The mechanism of insulin secretion is important in glucose metabolism. The deficiency of insulin secretion from pancreatic βcells will result in non-insulin dependent diabetes mellitus. In the pancreatic βcells, the insulin secretion is regulated by calcium-dependent regulative exocytosis of large dense-cored vesicles. Intracellular Ca^2+ plays an important role in regulating insulin-containing granules.The pancreatic βcells could change concentration of intracellular Ca^2+ by membrane KATP channels, Ca^2+ channels and intracellular Ca^2...