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Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes

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成果类型:
期刊论文
作者:
Yunyi Wang;Ke Xu;Xiao Gao;Zhaolan Wei;Qi Han;...
通讯作者:
Mingqing Chen
作者机构:
[Ke Xu; Qi Han; Shuxin Wang; Xiao Gao; Zhaolan Wei; Yunyi Wang; Wanting Du] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, 430079, Wuhan, Hubei, China
[Mingqing Chen] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, 430079, Wuhan, Hubei, China. chenmq@mail.ccnu.edu.cn
通讯机构:
[Mingqing Chen] H
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, China
语种:
英文
关键词:
AKT;FoxO1;Functional groups;Nanoplastics;Type 2 diabetes
期刊:
Particle and Fibre Toxicology
ISSN:
1743-8977
年:
2024
卷:
21
期:
1
页码:
1-14
基金类别:
This work was supported by the National Natural Science Foundation of China (42277437).
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
Increasing attention is being paid to the environmental and health impacts of nanoplastics (NPs) pollution. Exposure to nanoplastics (NPs) with different charges and functional groups may have different adverse effects after ingestion by organisms, yet the potential ramifications on mammalian blood glucose levels, and the risk of diabetes remain unexplored. Mice were exposed to PS-NPs/COOH/NH2 at a dose of 5 mg/kg/day for nine weeks, either alone or in a T2DM model. The findings demonstrated that exposure to PS-NPs modified by different functional groups caused a notable rise in fasting blood ...

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