期刊论文

Liu, Ke;Min, JR

英文

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS

1874-9399

2024

1867

1

194952

10.1016/j.bbagrm.2023.194952

In 2018, several C-terminal degradation signals were identified in human proteins, which can be recognized by the CRL E3 ligases as well as other E3s (Fig. 4) [62,63]. The Gly/C-degron was recognized by the Kelch-repeat domain-containing component of the CRL2 complexes, such as KLHDC2 [64], KLHDC3 [65], and KLHDC10 [66], and each recognin recognizes a distinct sequence motif. KLHDC2 prefers the C-end motif of -GG, KLHDC3 recognizes the −R/KG C-end motif and KLHDC10 targets the −A/W/PG C-end

本校为第一且通讯机构

Ubiquitination is a fascinating post-translational modification that has received continuous attention since its discovery. In this review, we first provide a concise overview of the E3 ubiquitin ligases, delving into classification, characteristics and mechanisms of ubiquitination. We then specifically examine the ubiquitination pathways mediated by the N/C-degrons, discussing their unique features and substrate recognition mechanisms. Finally, we offer insights into the current state of development pertaining to inhibitors that target the N/C-degron pathways, as well as the promising advance...