期刊论文

中文

环境科学学报

0253-2468

2008

28

5

995-1000

10.3321/j.issn:0253-2468.2008.05.030

国家科技支撑计划项目（No.2006BAI19B05-2）； 国家自然基金面上项目（No.30570799）~~；

本校为第一机构

为探讨邻苯二甲酸二乙基己酯[di-(2-ethylhexyl)phthalate,DEHP]在诱发哮喘和哮喘发病机理方面的作用,将Wistar大鼠随机分为正常组、卵清白蛋白(OVA)致敏组和DEHP染毒组,每组8只.用OVA致敏加激发的方法制作大鼠哮喘模型.DEHP染毒组分为2个组,每天分别给予0.7mg·kg~(-1)和70mg·kg~(-1)邻苯二甲酸二乙基己酯灌胃,连续30d.OVA致敏组、DEHP染毒组大鼠均在第31d给予1%OVA雾化,诱发哮喘.第38d测定大鼠在不同氯化乙酰甲胆碱(MCH)剂量下的肺功能,进行支气管肺泡灌洗液(BALF)的嗜酸性粒细胞(EOS)计数.结果显示,与OVA组相比,DEHP染毒组气道高反应性增强,嗜酸性粒细胞比例明显增多(P

The relationship between phthalate esters and asthma is a hot issue in international environmental medicine, especially as the global phthalate ester industry expands. To explore di-（2-ethylhexyl）phthalate （DEHP） induced asthma and investigate the potential role of DEHP in the pathogenesis of asthma, Wistar rats were randomized into four groups： control group, （OVA）-immunized asthma group and DEHP treatment groups which were lavaged with 0.7 mg· kg^-1 and 70 mg·kg^-1 DEHP for 30 d before and during OVA immunization. To evaluate the deg...