期刊论文

Yang, X.

中文

环境科学学报

0253-2468

2013

33

3

867-871

10.13671/j.hjkxxb.2013.03.010

湖北省教育厅科学技术研究项目

本校为通讯机构

毒死蜱是一种高效、低毒、广谱的有机磷杀虫杀螨剂.为研究其对生物体的氧化损伤,以昆明小鼠为受试体,毒死蜱按3、6和12 mg?kg~(-1)3个剂量水平灌胃染毒小鼠7 d,以脑组织匀浆测定活性氧(Reactive oxygen species,ROS)、还原型谷胱甘肽(Glutathione,GSH)和丙二醛(Malondialdehyde,MDA)的含量,以脑细胞测定DNA-蛋白质交联(DNA-protein Crosslink,DPC)系数.实验结果表明,随着毒死蜱染毒剂量的升高,ROS和MDA含量及DPC系数逐渐上升,GSH含量逐渐降低,各指标呈一定的剂量-效应关系.染毒剂量为6 mg?kg~(-1)时,与对照组相比,DPC有显著差异(p

Chlorpyrifos is an efficient, low toxicity, broad-spectrum organophosphorus insecticide acaricide. This study aims at identifying the oxidative stress effects of chlorpyrifos on organisms. Kunming mice were orally administrated with chlorpyrifos daily for seven days at the concentration of 3, 6 and 12 mg·kg-1, respectively. The contents of reactive oxygen species (ROS), glutathione (GSH) and malondialdehyde (MDA) in the brain homogenate and DNA-protein Crosslink (DPC) coefficients in the brain cells were measured to indicate the oxidative dama...