期刊论文

Yang, X.

中文

环境科学学报

0253-2468

2014

34

2

507-513

10.13671/j.hjkxxb.2014.02.005

国家科技支撑计划项目（No.2012BAJ02B03）； 国家自然科学基金重点项目（No.51136002）~~；

本校为第一且通讯机构

单壁碳纳米管(single walled carbon nanotubes, SWCNTs)是纳米材料研究关注的焦点之一. 尽管如此,关于其神经毒性的研究相对较少. 本研究将SWCNTs 以不同的浓度(0 mg·kg~(-1)·d~(-1), 3. 125 mg·kg~(-1)·d~(-1), 6. 25 mg·kg~(-1)·d~(-1), 12. 5 mg·kg~(-1)·d~(-1)),通过腹腔注射于Kunming 小鼠体内. 神经行为学实验(旷场实验)结果表明,在一定浓度的SWCNTs 作用下,小鼠的情绪受到一定的影响,具有抑郁症的特征,出现移动能力下降,紧张等现象. 同时小鼠脑部组织的活性氧族(reactive oxygen species, ROS)和丙二醛(malondialdehyde, MDA)水平升高(p

Single-walled carbon nanotubes (SWCNTs) have been one of the focuses of nanometer materials research. The research about its neurotoxicity is however limited. In this study, SWCNTs were accumulated in the mice of different experimental groups (0 mg·kg-1·d-1, 3.125 mg·kg-1·d-1, 6.25 mg·kg-1·d-1, 12.5 mg·kg-1·d-1)though intraperitoneal injection. Results of open-fielded experiment showed that under certain concentrations of SWCNTs, emotions in mice were affected to some extent, with the characteristics of depression, decline of mobile abi...