期刊论文

Oxidative damage mechanism of learning and memory impairment caused by diisodecyl phthalate and formaldehyde in mice

Ma, P.

中文

环境科学学报

0253-2468

2018

38

10

4185-4194

10.13671/j.hjkxxb.2018.0218

No.T201717:湖北省高等学校优秀中青年科技创新团队项目 No.WJ20172027:湖北省卫生计生委重点支撑项目 No.201710927030:湖北省大学生创新训练项目

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为了探究邻苯二甲酸二异癸酯(Diisodecyl Phthalate,DIDP)、甲醛(Formaldehyde,FA)二者联合暴露致小鼠学习记忆障碍的氧化损伤机制,以及维生素E(Vitamin E,VitE)对二者所致氧化损伤的保护作用,将80只SPF级3周龄雄性KM小鼠随机平均分为8组:(A)阴性对照组; (B)0.15 mg·kg~(-1)·d~(-1) DIDP组;(C)1.5 mg·kg~(-1)·d~(-1) DIDP组;(D)15 mg·kg~(-1)·d~(-1) DIDP组;(E)150 mg·kg~(-1)·d~(-1) DIDP组;(F)1 mg·m~(-3) FA组; (G)1 mg·m~(-3) FA+15 mg·kg~(-1)·d~(-1) DIDP组;(H)1 mg·m~(-3) FA+15 mg·kg~(-1)·d~(-1) DIDP+100 mg·kg~(-1)·d~(-1) VitE组.连续染毒3周.于染毒第13 d开始进行...

To explore oxidative damage mechanism of learning and memory impairment induced by diisodecyl phthalate (DIDP) and formaldehyde (FA) in mice, and the the protective effect of vitamin E (Vit E). 80 SPF 3-week-old male KM mice were randomly divided into 8 groups: (A) negative control group; (B) 0.15 mg•kg-1•d-1 DIDP group; (C) 1.5 mg•kg-1•d-1 DIDP group; (D) 15 mg•kg-1•d-1 DIDP group; (E) 150 mg•kg-1•d-1 DIDP group; (F) 1 mg•m-3 FA group; (G) 1 mg•m-3 FA+15 mg•kg-1•d-1 DIDP group; (H) 1 mg•m-3 FA+15 mg•kg-1•d-1 DIDP+100 mg•kg-1•d...