期刊论文

Study on the organ injury and inflammatory response in mice induced by intratracheal exposure of nAl_2O_3

Li, R.

中文

环境科学学报

0253-2468

2019

39

3

969-977

10.13671/j.hjkxxb.2018.0367

“十三五”国家重点研发计划（No.2017YFC0702700）；

本校为第一且通讯机构

为探讨纳米氧化铝(nAl_2O_3)气道滴注对小鼠脏器的毒性作用,本研究将Balb /c小鼠随机分成6组:生理盐水组、50 mg·kg~(-1)·d~(-1) Vit E(维生素E)组、0.5 mg·kg~(-1)·d~(-1) nAl_2O_3组、5 mg·kg~(-1)·d~(-1) nAl_2O_3组、50 mg·kg~(-1)·d~(-1) nAl_2O_3组、nAl_2O_3 50+Vit E组(50 mg·kg~(-1)·d~(-1) nAl_2O_3 +50 mg·kg~(-1)·d~(-1)Vit E) .实验周期为21 d,气道滴注暴露,隔天滴注,维生素E灌胃阻断.染毒结束后,检测肺部、脾脏、肝脏和肾脏中活性氧(Reactive Oxide Species,ROS)和还原型谷胱甘肽(Glutathione,GSH)含量,并进行肺部病理学观察和肺泡灌洗液细胞计数.结果表明:与对照组相...

To investigate the toxic effects on mice by intratracheal instillation of nAl2O3, male Balb/c mice were randomly divided into six groups: saline group, 50 mg•kg-1•d-1 Vitamin E group, 0.5 mg•kg-1•d-1 nAl2O3 group, 5 mg•kg-1•d-1 nAl2O3 group, 50 mg•kg-1•d-1 nAl2O3 group, nAl2O3 50+Vit E group. For consecutive 21 days, mice were intratracheally instilled once every other day and gavaged with Vitamin E. The ROS and GSH contents in lung, spleen, liver, and kidney were measured, the pathology in lung was observed and the cell number in the a...