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Design, synthesis and mechanism research of novel algicide based on bioactive fragments synthesis strategy

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成果类型:
期刊论文
作者:
Huang, Shi;Zuo, Lingzi;Cheng, Guonian;He, Yanlin;Zhang, Liexiong;...
通讯作者:
Lingling Feng
作者机构:
[He, Yanlin; Han, Qiang; Zuo, Lingzi; Zhang, Liexiong; Cheng, Guonian; Huang, Shi; Feng, Lingling] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Lingling Feng] K
Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
语种:
英文
关键词:
1,3,4-thiadiazole thioacetamide;Algicidal activity;Harmful cyanobacterial blooms;Mechanism;Photosynthesis
期刊:
Pesticide Biochemistry and Physiology
ISSN:
0048-3575
年:
2023
卷:
191
页码:
105344
基金类别:
National Natural Science Foundation of China [22277037, 21877046, 21472061, 21272089]; Fundamental Research Funds for the Central Universities [CCNU18ZDPY02, CCNU18TS010, CCNU16A02041, CCNU14A05006]; Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]
机构署名:
本校为第一机构
院系归属:
化学学院
摘要:
The frequency and intensity of harmful cyanobacterial blooms (HCBs) are increasing all over the world, their prevention and control have become a great challenge. In this paper, a series of 1,3,4-thiadiazole thioacetamides (T series) were designed and synthesized as potential algaecides. Among them, the compound T3 showed its best algacidal activity against Synechocystis sp. PCC 6803 (PCC 6803, EC50 = 1.51 mu M) and Microcystis aeruginosa FACHB 905 (FACHB905, EC50 = 4.88 mu M), which was more effective than the lead compound L1 (PCC6803, EC50 = 7.7 mu M; FACHB905, EC50 = 8.8 mu M) and the comm...

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