Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer\'s disease - 成果

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Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease

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成果类型：

期刊论文

作者：

Tong, Zhiqian;Han, Chanshuai;Qiang, Min;Wang, Weishan;Lv, Jihui;...

通讯作者：

He, Rongqiao

作者机构：

[Su, Tao; Wu, Beibei; He, Rongqiao; Qiang, Min; Liu, Ying; Tong, Zhiqian; Han, Chanshuai] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100864, Peoples R China.

[He, Rongqiao; Wang, Xiaomin; Tong, Zhiqian] Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing, Peoples R China.

[Su, Tao; Wu, Beibei; Qiang, Min; Han, Chanshuai] Univ Chinese Acad Sci, Beijing, Peoples R China.

[Wang, Weishan; Zhang, Shouzi; Lv, Jihui] Beijing Geriatr Hosp, Beijing, Peoples R China.

[Luo, Hongjun; Li, Hui; Luo, Wenhong] Shantou Univ, Coll Med, Cent Lab, Guangdong, Peoples R China.

通讯机构：

[He, Rongqiao] C

Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100864, Peoples R China.

语种：

英文

关键词：

Endogenous formaldehyde;DNA methyltransfarases (DNMTs);Topographic amnesia;Alzheimer's disease (AD)

期刊：

Neurobiology of Aging

ISSN：

0197-4580

年：

2015

卷：

期：

页码：

100-110

DOI：

10.1016/j.neurobiolaging.2014.07.018

基金类别：

973-ProjectNational Basic Research Program of China [2012CB911004, 2010CB912303]; Chinese Postdoctoral Fund [20090460047]; General and Special Program of the Postdoctoral Science Foundation of China [2012T50144]; External Cooperation Program of BIC, Chinese Academy of sciences [GJHZ201302]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31171080, 30970695]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Hippocampus-related topographic amnesia is the most common symptom of memory disorders in Alzheimer's disease (AD) patients. Recent studies have revealed that experience-mediated DNA methylation, which is regulated by enzymes with DNA methyltransferase (DNMT) activity, is required for the formation of recent memory as well as the maintenance of remote memory. Notably, overexpression of DNMT3a in the hippocampus can reverse spatial memory deficits in aged mice. However, a decline in global DNA methylation was found in the autopsied hippocampi of patients with AD. Exactly, what endogenous factor...

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Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease

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