Let G be a finite group. A subgroup H of G is called a 2-maximal subgroup of G if there exists a maximal subgroup M of G such that H is a maximal subgroup of M. In this paper, we discuss the influence of π-quasinormality of 2-maximal subgroups of Sylow subgroups on the structure of a finite group, and obtain some sufficient conditions under which the finite group is p-nilpotent, s...