期刊论文

Wu, An-Xin

英文

中国化学快报：英文版

1001-8417

2015

26

7

881-884

10.1016/j.cclet.2014.12.016

We would like to thank the National Natural Science Founda- tion of China （Nos. 21032001 and 21272085） for their generous financial support. We acknowlege the excellent doctorial disserta- tion cultivation grant from Central China Normal University Wuhan, China （No. 2013YBYBB3）. We also thank Dr. Chuanqi Zhou, Hebei University, for analytical support.

本校为第一且通讯机构

An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[1,2-a]pyridines from easily available starting materials: Aromatic ketones, α,β-unsaturated ketones, β-keto esters and 2-aminopyridines. The present reaction proceeded well in MeOH under the media of I2/CuO. By using this method, the marketed drug zolimidine could be prepared easily with 95% yield. All these target products were characterized by NMR, HRMS and IR spectra. Furthermore, the target compound 3fa was determined by X-ray crystallographic analysis. ©...