This work was financially supported by the Start-up Funding from South-Central University for Nationalities (No. YZZ19005 ) and the National Key Research and Development Program of China (No. 2018YFD0200102 ), the National Natural Science Foundation of China (Nos. 21911530178 and 21772055 ), the 111 Project (No. B17019 ) and self-determined research funds of CCNU from the colleges’ basic research and operation of MOE, the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine) (No. WDCM2019003 ).