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Pillar[5]arene-functionalized nanochannel platform for detecting chiral drugs

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成果类型:
期刊论文
作者:
Yu, Sheng;Wang, Yaqi;Chatterjee, Sobhan;Liang, Feng*;Zhu, Fei;...
通讯作者:
Liang, Feng;Li, Haibing
作者机构:
[Chatterjee, Sobhan; Liang, Feng; Yu, Sheng; Wang, Yaqi] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Wuhan 430081, Peoples R China.
[Li, Haibing; Zhu, Fei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Liang, Feng] W
[Li, Haibing] C
Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Wuhan 430081, Peoples R China.
Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Chiral recognition;Pillar[5]arene;Bionic nanochannel;Electrochemical sensor;Chiral drugs
期刊:
中国化学快报:英文版
ISSN:
1001-8417
年:
2021
卷:
32
期:
1
页码:
179-183
基金类别:
financially supported by the National Key Research and Development Program of China (No. 2018YFD0200102); the National Natural Science Foundation of China (Nos. 21772055, 21572076, 21807083, 21911530178); the Program for Innovative Teams of Outstanding Young and Middleaged Researchers in the Higher Education Institutions of Hubei Province (No. T201702); the 111 Project (No. B17019E);
机构署名:
本校为通讯机构
院系归属:
化学学院
摘要:
Chirality is a fascinating and essential feature of life and highly associated with many significant pharmaceutical, chemical, and biological processes. The construction of chiral recognition platform is a hot research topic and challenging assignment. Herein, we report an electrochemical method by differential pulse voltammetry (DPV) for the enantioselective recognition of chiral drug propranolol (R/S-PPL) through a nanochannel platform based on the N-acetyl-L-cysteine functionalized pillar[5]arenes derivative NALC-P5 and the porous polycarbonate membrane. The chiral discrimination depends on...

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