Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

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成果类型：

期刊论文

作者：

Zhu, Hongda;Ma, Kai;Ruan, Rui;Yang, Chaobo;Yan, Aqin;...

通讯作者：

Zhu, HD;Dai, Z;Sun, Y

作者机构：

[Ruan, Rui; Ma, Kai; Yu, Qi; Yang, Chaobo; Yan, Aqin; Sun, Hongmei; Zhu, Hongda; Liu, Mingxing; Zhu, HD] Hubei Univ Technol, Cooperat Innovat Ctr Ind Fermentat, Natl 111 Ctr Cellular Regulat & Mol Pharmaceut,Key, Sch Food & Biol Engn,Minist Educ & Hubei Prov, Wuhan 430068, Peoples R China.

[Zheng, Hongmei; Li, Jing; Dai, Zhu] Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Wuhan 430079, Peoples R China.

[Sun, Y; Yu, Qi; Sun, Yao] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

[Gao, Jing] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Key Lab Med Opt, Suzhou 215163, Peoples R China.

[Guan, Xiaofang] Qingdao Univ Sci & Technol, Minist Educ, Key Lab Opt Elect Sensing & Analyt Chem Life Sci, Qingdao 266042, Peoples R China.

通讯机构：

[Sun, Y ] C

[Zhu, HD ; Dai, Z ] H

Hubei Univ Technol, Cooperat Innovat Ctr Ind Fermentat, Natl 111 Ctr Cellular Regulat & Mol Pharmaceut,Key, Sch Food & Biol Engn,Minist Educ & Hubei Prov, Wuhan 430068, Peoples R China.

Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Wuhan 430079, Peoples R China.

Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

Immunotherapy;Tumor-targeted;Self-assembled micelles;Metformin;Reducing PD-L1 expression;TNBC

期刊：

中国化学快报：英文版

ISSN：

1001-8417

年：

2024

卷：

期：

页码：

108536

DOI：

10.1016/j.cclet.2023.108536

基金类别：

National Key Research and Development Program [2021YFA0716702]; National Natural Science Foundation of China [61805122, 22022404, 22074050]; Green Industry Science and Technology Leading Project of Hubei University of Technology [XJ2021003301]; National Natural Science Foundation of Hubei Province [2022CFA033]; Chinese Society of Clinical Oncology (CSCO) - Jiangsu Hengrui Cancer Research Foundation; Fundamental Research Funds for the Central Universities [JKLMO202203]; Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology [M2022-5]; Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MO [YHR2019-0325]; [CCNU22QN007]

机构署名：

本校为通讯机构

院系归属：

化学学院

摘要：

Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death ligand 1 (PD-L1) and programmed death protein 1 (PD-1) had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer (TNBC). However, the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of immunotherapy. Herein, the immunomodulator epigallocatechin gallate palmitate (PEGCG) and the immunoadjuvant metformin (MET) self-assembled into tumor-targeted mic...

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Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

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