Hypoxia-Activatable Nanovesicles as In Situ Bombers for Combined Hydrogen-Sulfide-Mediated Respiration Inhibition and Photothermal Therapy

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成果类型：

期刊论文

作者：

Yu, Qi;Tu, Le;Zhu, Ting;Zhu, Hongda;Liu, Shujuan;...

通讯作者：

Yu, Qi(iamqyu@outlook.com);Sun, Yao(sunyaogbasp@mail.ccnu.edu.cn);Zhao, Qiang(iamqzhao@njupt.edu.cn)

作者机构：

[Zhu, Hongda; Yu, Qi] Hubei Univ Technol, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Sch Food & Biol Engn, Key Lab Fermentat Engn,Minist Educ,Hubei Key Lab I, Wuhan 430068, Peoples R China.

[Tu, Le; Sun, Yao] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.

[Zhao, Qiang; Zhu, Ting; Liu, Shujuan] Nanjing Univ Posts & Telecommun NUPT, State Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China.

[Zhao, Qiang; Zhu, Ting; Liu, Shujuan] Nanjing Univ Posts & Telecommun NUPT, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, Nanjing 210023, Peoples R China.

[Zhao, Qiang; Zhu, Ting; Liu, Shujuan] Nanjing Univ Posts & Telecommun NUPT, Inst Flexible Elect Future Technol, Nanjing 210023, Peoples R China.

通讯机构：

[Qi Yu; Yao Sun] K

[Qiang Zhao] S

Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China<&wdkj&>Key Laboratory of Fermentation Engineering (Ministry of Education), National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, P.R. China<&wdkj&>State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) & Institute of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210023, P.R. China

语种：

英文

关键词：

hypoxic environment;hydrogen sulfide;mitochondria respiration inhibition;nanovesicles;photothermal therapy

期刊：

ACS Applied Materials & Interfaces

ISSN：

1944-8244

年：

2022

卷：

期：

页码：

50637-50648

DOI：

10.1021/acsami.2c15844

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant Nos. 61805122, 22075148, and 22074050), the Fundamental Research Funds for the Central Universities (Grant No. CCNU22QN007), the Open Project Funding of the Key Laboratory of Fermentation Engineering (Ministry of Education, 202105FE06), the Collaborative Grant-in-Aid of the HBUT National “111” Center for Cellular Regulation and Molecular Pharmaceutics (XBTK-2021012), the Open Project Funding of Hubei Province Key Laboratory of Occupational Hazard Identification and Control (OHIC2021G02), and Green Industry Science and Technology Leading Project of Hubei University of Technology (XJ2021003301).

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本校为其他机构

院系归属：

化学学院

摘要：

Photothermal therapy (PTT) has emerged as a promising alternative or supplement to cancer treatments. While PTT induces the ablation of solid tumors, its efficiency is hampered by self-recovery within impaired cancer cells through glycolysis and respiration metabolism. Based on this, the introduction of hydrogen sulfide (H2S)-mediated respiration inhibition is a good choice to make up for the PTT limitation. Herein, nanovesicles (NP1) are integrated by a hypoxia-responsive conjugated polymer (P1), polymetric H2S donor (P2), and near-infrared (N...

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Hypoxia-Activatable Nanovesicles as In Situ Bombers for Combined Hydrogen-Sulfide-Mediated Respiration Inhibition and Photothermal Therapy

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