期刊论文

Jia, Chen-Yang

英文

Drug Discovery Today

1359-6446

2020

25

1

248-258

10.1016/j.drudis.2019.10.014

This research was supported, in part, by the National Key R&D Program ( 2017YFD0200501 ), the National Natural Science Foundation of China (No. 21772059 , 91853127 , and 31960548 ).

本校为第一且通讯机构

Undesirable pharmacokinetic (PK) properties or unacceptable toxicity are the main causes of the failure of drug candidates at the clinical trial stage. Since the concept of drug-likeness was first proposed, it has become an important consideration in the selection of compounds with desirable bioavailability during the early phases of drug discovery. Over the past decade, online resources have effectively facilitated drug-likeness studies in an economical and time-efficient manner. Here, we provide a comprehensive summary and comparison of current accessible online resources, in terms of their ...