期刊论文

Wu, Yan-Doug;Wu, An-Xin

英文

Organic Letters

1523-7060

2019

21

13

4939-4943

10.1021/acs.orglett.9b01277

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472056, 21602070, 21772051]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU15ZX002, CCNU18QN011]; 111 ProjectMinistry of Education, China - 111 Project [B17019]

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A N–H/α,β-C(sp3)-trifunctionalization of l-proline, proceeding through an iodine-promoted consecutive decarboxylation/ring-opening/dicyclization process, is achieved. This strategy affords structurally diverse fused N-heterocycles in good yields with a wide substrate scope. Preliminary mechanistic studies indicate that catabolism of l-proline might be involved in this cascade reaction and the in situ generated intermediate 4-aminobutanal was identified as the key intermediate. Notably, this domino strategy enriches the reac...