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A study on the acute irritation responses and molecular mechanism of gaseous formaldehyde

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成果类型:
期刊论文、会议论文
作者:
He, HJ;Liu, HL;Wu, J;Lu, ZS;Yan, Y;...
通讯作者:
Yang, X
作者机构:
[He, HJ; Lu, ZS; Wu, J; Yan, Y; Li, CM; Liu, HL; Yang, X] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
通讯机构:
[Yang, X] C
Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
IAQ;formaldehyde;blinking frequency;irritant intensity;substance P
期刊:
INDOOR AIR 2005: PROCEEDINGS OF THE 10TH INTERNATIONAL CONFERENCE ON INDOOR AIR QUALITY AND CLIMATE, VOLS 1-5
ISSN:
0908-5920
年:
2005
卷:
15
页码:
3691-3695
会议名称:
10th International Conference on Indoor Air Quality and Climate (Indoor Air 2005)
会议时间:
SEP 04-09, 2005
会议地点:
Beijing, PEOPLES R CHINA
会议主办单位:
Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
会议赞助商:
Tsinghua Univ, Minist Educ China, Natl Nat Sci Fdn China, Beijing Municipal Commiss Sci & Technol, Shanghai Municipal Commiss Sci & Technol, US EPA, Amer Ind Hyg Assoc, Amer Soc Heating, Refrigerating & Air Conditioning Engineers, Int Commiss Occupat Hlth, SC Indoor Air Qual & Hlth, Int Council Res & Innovat Bldg & Construct, European Commiss Asia Pro Eco Programme Promot Sustainable Solut Environm Europe & Asia, Korean Soc Indoor Environm, Soc Indoor Environm
主编:
Yang, X Zhao, B Zhao, R
出版地:
TSINGHUA UNIV HAIDIANQU, BEIJING 100084, PEOPLES R CHINA
出版者:
TSINGHUA UNIV PRESS
ISBN:
978-7-89494-830-4
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
To find out reliable biomarkers in China for acute irritation caused by indoor air pollutants, we carried out this study. A controlled human exposure experiment was used as the main research method. Subject eyes were exposed to gaseous formaldehyde at different doses (0 mg/m(3), 1.0 mg/m(3) 2.0 mg/m(3), 3.0 mg/m(3)) five minutes a day for 4 days. The content of substance P in nasal lavage was determined by radio immune assay (RIA), and the blinking frequency and irritant intensity of their eyes were measured at the same time. The results showed that there were dose-dependent effects between bl...

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