To find out reliable biomarkers in China for acute irritation caused by indoor air pollutants, we carried out this study. A controlled human exposure experiment was used as the main research method. Subject eyes were exposed to gaseous formaldehyde at different doses (0 mg/m3, 1.0 mg/m3, 2.0 mg/m3, 3.0 mg/m3) five minutes a day for 4 days. The content of substance P in nasal lavage was determined by radio immune assay (RIA), and the blinking frequency and irritant intensity of their eyes were measured at the same time. The results showed that t...
