期刊论文

Yin, Jun;Zeng, Lintao

英文

Talanta

0039-9140

2017

170

406-412

10.1016/j.talanta.2017.04.038

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21676113, 21402057, 21472059]; Youth Chen-Guang Project of Wuhan [2016070204010098]; Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Shenzhen; Ministry of Education; self-determined research funds of CCNU from the colleges' basic research and operation of MOE [CCNU16A02004]

本校为第一且通讯机构

A new ratiometric fluorescent probe based on a hemicyanine dye was synthesized. Investigation on the response behavior towards amino acids showed that the probe had a capability of rapidly and selectively detecting cysteine over other biothiols such as glutathione and homocysteine with similar structure and reactivity, and it also displayed a high selectivity and rapid response. Moreover, the probe had good water solubility, which authorized it could be applied in fluorescent bioimaging. The laser confocal fluorescence images indicated that the probe could visualize the intracellular cysteine....