An enzyme activated fluorescent probe for LTA4H activity sensing and its application in cancer screening

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成果类型：

期刊论文

作者：

Wan, Xingxia;Wang, Huiling;Shi, Baotang;Guo, Yu;Liu, Shi-Yu;...

通讯作者：

Shi-Yu Liu<&wdkj&>Xianwang Wang

作者机构：

[Wan, Xingxia; Shi, Baotang; Guo, Yu; Liu, Shi-Yu; Wang, Xianwang] Yangtze Univ, Hlth Sci Ctr, Ctr Mol Med, Dept Biochem & Mol Biol, Jingzhou 434023, Hubei, Peoples R China.

[Wan, Xingxia; Shi, Baotang; Liu, Shi-Yu] Yangtze Univ, Hlth Sci Ctr, Dept Lab Med, Jingzhou 434023, Hubei, Peoples R China.

[Wang, Huiling] Cent China Normal Univ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China.

通讯机构：

[Shi-Yu Liu; Xianwang Wang] D

Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, 434023, PR China<&wdkj&>Department of Laboratory Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, 434023, PR China<&wdkj&>Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, 434023, PR China

语种：

英文

关键词：

Cancer screening;Fluorescent probe;Leukotriene A4 hydrolase;Living imaging

期刊：

Talanta

ISSN：

0039-9140

年：

2023

卷：

253

页码：

123887

DOI：

10.1016/j.talanta.2022.123887

基金类别：

National Natural Science Foundation of China [31700736, 22107012]; China Scholarship Council [201908420102]; Hubei Province Scientific and Technological Research Project [D20201306]; Hubei Province Health Research Project [WJ2019-01]; Hubei Medical Youth Tip-Top Talent; Leading Talent Program of Yangtze Talent Project; College Students Innovative Entrepreneurial Training Program in Yangtze University [Yz2021296, Yz2020334]; Scientific Research and Development Fund Project of Yangtze University [8021002902]

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Early diagnosis of cancer is an efficient strategy to prevent tumor progression and improve the survival rate of patients. However, to discovery of reliable tumor-specific biomarkers remains a great challenge. Leukotriene A4 hydrolase (LTA(4)H) is a bifunctional zinc metalloenzyme with epoxide hydrolase activity and aminopeptidase activity, which plays important roles in allergic and inflammatory reactions and showed strong relevance with carcinoma progression. We thus sought to investigate the possibility of application LTA(4)H activity detection in cancer diagnosis. To achieve this, we herei...

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An enzyme activated fluorescent probe for LTA4H activity sensing and its application in cancer screening

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