Induction of GSNO reductase but not NOS in the lungs of mice exposed to glucan-spiked dust

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成果类型：

期刊论文

作者：

Cao, Yi;Liang, Sisi;Zheng, Yuduo;Liu, Dandan;Zhang, Benyan;...

通讯作者：

Yang, Xu

作者机构：

[Liu, Dandan; Liang, Sisi; Yang, Xu; Cao, Yi; Zheng, Yuduo] Huazhong Normal Univ, Coll Life Sci, Lab Environm Sci, Wuhan 430079, Peoples R China.

[Liu, Dandan; Liang, Sisi; Yang, Xu; Cao, Yi; Zheng, Yuduo] Huazhong Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

[Zhang, Benyan] Wuhan Univ Sci & Technol, Coll Med, Dept Environm & Occupat Hlth, Wuhan 430065, Peoples R China.

[Xu, Dongqun] China Natl Ctr Dis Control & Prevent, Inst Environm Hlth & Related Prod Safety, Beijing 100021, Peoples R China.

通讯机构：

[Yang, Xu] H

Huazhong Normal Univ, Coll Life Sci, Lab Environm Sci, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

glucan-spiked dust;GSNO reductase;nitric oxide;NOS

期刊：

ENVIRONMENTAL TOXICOLOGY

ISSN：

1520-4081

年：

2011

卷：

期：

页码：

279-286

DOI：

10.1002/tox.20554

基金类别：

China Key Technologies RD Programs [2006BAI19B05, 2006BAJ02A10]

机构署名：

本校为第一且通讯机构

院系归属：

城市与环境科学学院

生命科学学院

摘要：

Both in vivo and in vitro studies have suggested that airborne organic dusts may induce inflammatory responses in the lungs, characterized by typical patterns of cytokine up-regulation and secretion. Recent work showed that exposure to glucan-spiked dust might influence nasal and pulmonary function, without an accompanying inflammatory response. However, effects of glucan-spiked dust exposure on NOS and GSNO reductase (enzymes important to NO signaling) remain less clear. This study aims to determine the effects of simultaneous exposure to gluc...

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Induction of GSNO reductase but not NOS in the lungs of mice exposed to glucan-spiked dust

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