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Novel Zinc Ion-Catalyzed Synthesis of Unsymmetric Multisubstituted Pyridines

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成果类型:
期刊论文
作者:
Ren, Qingyun;Mo, Wenyan;Yao, Yongyan;He, Hongwu*;Gu, Yucheng
通讯作者:
He, Hongwu
作者机构:
[He, Hongwu; Yao, Yongyan; Gu, Yucheng; Mo, Wenyan; Ren, Qingyun] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
[Gu, Yucheng] Jealotts Hill Int Res Ctr, Bracknell, Berks, England.
[He, Hongwu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[He, Hongwu] C
Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
期刊:
Synthetic Communications
ISSN:
0039-7911
年:
2009
卷:
40
期:
2
页码:
303-312
基金类别:
National Key Project for Basic Research Development Program of China [2003CB114400]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [20772042]; National Science and Technique Foundation of China [2006BAE01A01-10]; Syngenta Ltd.
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A facile and convenient synthesis of unsymmetric multisubstituted pyridines from β-ketoesters and ketene N,S-acetals or ketene N,N-acetals has been achieved in good yields catalyzed by Zn(NO3)2·6H2O in the presence of triethylbenzylammonium (TEBA) chloride in ethanol. This reaction was carried out under economical, one-pot reaction conditions (using easily obtained starting materials, and inexpensive catalyst and solvent) and offers consi...

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