To detect its effect on the hepatoma cell's proliferation and changes of the SOD activity and the content of protein within cells and culture mediums. Mimics of SOD (MSOD) were added into human hepatoma SSMC-7721 cell lines. The results showed that this MSOD had activities of SOD and could penetrate the cells to increase the activity of intracellular SOD. And the increase of SOD activities might be one of the reasons why this drug could restrain proliferation of the hepatoma cell lines. [Conclusion] This research will offer im...