Molecular Insight into the Extracellular Chaperone Serum Albuminin Modifying the Folding Free Energy Landscape of Client Proteins br

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成果类型：

期刊论文

作者：

Jin, Yangzhuoyue;Yu, Gangjin;Yuwen, Tairan;Gao, Dawei;Wang, Guan;...

通讯作者：

He, LC

作者机构：

[Wang, Guan; Jiang, Bin; Li, Conggang; He, Lichun; Jin, Yangzhuoyue; Yu, Gangjin; Liu, Maili; Zhang, Xu; He, LC] Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom Mol Phys, Wuhan 430071, Hubei, Peoples R China.

[Wang, Guan; Jiang, Bin; Li, Conggang; He, Lichun; Jin, Yangzhuoyue; Yu, Gangjin; Liu, Maili; Zhang, Xu; He, LC] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Yuwen, Tairan] Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut Anal, Beijing 100871, Peoples R China.

[Yuwen, Tairan] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China.

[Gao, Dawei] Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China.

通讯机构：

[He, LC ] C

Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom Mol Phys, Wuhan 430071, Hubei, Peoples R China.

Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

语种：

英文

期刊：

Journal of Physical Chemistry Letters

ISSN：

1948-7185

年：

2022

卷：

期：

页码：

2711-2717

DOI：

10.1021/acs.jpclett.2c00265

基金类别：

National Key R&D Program of China [2018YFE0202301, 2018YFE0202300]; National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [22174151, 21904138, 21991080, 22078280]

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Serum albumin (SA) is the most abundant extracellular chaperone protein presenting in various bodily fluids. Recently, several studies have revealed molecular mechanisms of SA in preventing the amyloid formation of amyloidogenic proteins. However, our insight into the mechanism SA employed to sense and regulate the folding states of full-length native proteins is still limited. Addressing this question is technically challenging due to the intrinsic dynamic nature of both chaperones and clients. Here using nuclear magnetic resonance spectroscop...

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Molecular Insight into the Extracellular Chaperone Serum Albuminin Modifying the Folding Free Energy Landscape of Client Proteins br

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