期刊论文

Ma, Ping;Wu, Yang

英文

Environmental Toxicology and Pharmacology

1382-6689

2016

45

45-51

10.1016/j.etap.2016.05.013

This work was funded by the Science and Technology Research Foundation from Hubei province Education Department ( Q20152801 ) and the Scientific Research Foundation for the PhD Start-up of Hubei University of Science and Technology ( BK1412 ).

本校为其他机构

Among all phthalate esters, dibutyl phthalate (DBP) is only second to di-(2-ethylhexyl) phthalate (DEHP) in terms of adverse health outcomes, and its potential cerebral neurotoxicity has raised concern in recent years. DBP exposure has been reported to be responsible for neurobehavioral effects and related neurological diseases. In this study, we found that neurobehavioral changes induced by DBP may be mediated by oxidative damage in the mouse brain, and that the co-administration of Mangiferin (MAG, 50 mg/kg/day) may protect the brain against oxidative damage caused by DBP exposure. The resul...