Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe

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成果类型：

期刊论文

作者：

Liu, Ye;Yu, Heng-Yi;Xu, Hong-Zhe;Liu, Jun-Jun;Meng, Xiang-Gao;...

通讯作者：

Ruan, Han-Li

作者机构：

[Ruan, Han-Li; Liu, Ye; Yu, Heng-Yi; Liu, Jun-Jun; Xu, Hong-Zhe; Zhou, Ming] Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.

[Liu, Ye] Wuhan Univ, Zhongnan Hosp, Med Sci Res Ctr, Wuhan 430071, Hubei, Peoples R China.

[Yu, Heng-Yi] Huazhong Univ Sci & Technol, Dept Pharm, Tongji Hosp, Affiliated Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.

[Meng, Xiang-Gao] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Ruan, Han-Li] H

Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.

语种：

英文

期刊：

JOURNAL OF NATURAL PRODUCTS

ISSN：

0163-3864

年：

2018

卷：

期：

页码：

1841-1849

DOI：

10.1021/acs.jnatprod.8b00324

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31770380, 21572073, 31270394, 31500282]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2016YXMS150]

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Ten new alkaloids (1-10), including two pairs of enantiomeric mixtures (5a,b and 6a,b), and 15 known analogues (11-25) were obtained from the bark of Pausinystalia yohimbe. The structures of 1-25 were established by spectroscopic methods, and the absolute configurations of compounds 1-10 were resolved by X-ray diffraction and ECD data analyses. The in vitro immunosuppressive activities of selected isolates were tested. Compounds 11 and 16 exhibited moderate inhibition with IC50 values of 16.8 and 27.6 mu M against ConA-induced T lymphocyte proliferation and 13.5 and 4...

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