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Mapping cryptic binding sites of drug targets to overcome drug resistance

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成果类型:
期刊论文
作者:
Gao, Yang-Yang;Yang, Wei-Cheng;Ashby Jr, Charles R.;Hao, Ge-Fei
通讯作者:
Charles R. Ashby
作者机构:
[Yang, Wei-Cheng; Gao, Yang-Yang; Hao, Ge-Fei] Guizhou Univ, Ctr Res & Dev Fine Chem, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China.
[Hao, Ge-Fei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
[Ashby Jr, Charles R.] St Johns Univ, Dept Pharmaceut Sci, New York, NY 10003 USA.
通讯机构:
[Charles R. Ashby] D
Department of Pharmaceutical Sciences, St. John’s University, New York, NY, USA
语种:
英文
关键词:
Drug resistance;Cryptic binding sites;Resistance management
期刊:
Drug Resistance Updates
ISSN:
1368-7646
年:
2023
卷:
67
页码:
100934
基金类别:
This work was supported by the National Natural Science Foundation of China (32125033).
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their ...

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